Oxygen consumption during thiocyanate inhibition of gastric acid secretion in dogs.

MOODY, FRANK G. Oxygen consumphn during thiocyanate irhibition of gastric acid secretion in dog. Am. J, Physiol. 2 15( 1) : 127-131. 1968.-The relationship between oxygen c&sumption, blood flow, and acid secretion was studied in exteriorized gastric se gments of the dog during histamine and thiocyanate administration. Acid secretion and oxygen consumption demonstrated a highly significant linear correlation (r = .83) during histamine administration by a direct arterial route. The ratio of hydrogen ions produced to oxygen molecules consumed was 2.7. 2.hiocyanate inhibition of acid secretion did not change the high rate of respiration which accompanied histamine administration. Total blood flow aLso did not decrease; aminopyrine clearance was not a reliable index of mucosal blood flow during thiocyanate inhibition. The disassociation of respiration from acid secretion suggests that thiocyanate may inhibit acid secretion at some point beyond the transfer of energy to the process.